Neural dynamics in stroke-related and progressive aphasia: Moving towards individualized treatment with noninvasive neuromodulation.
Aphasia is an acquired language disorder that can affects person’s ability to speak, read, write and understand language. Aphasia can result from damage to the brain regions involved in language processing, usually in the left hemisphere. Most often this syndrome occurs after the stroke and it can lead to the chronic impairment. Another type of aphasia results from the progressive atrophy to the brain regions that support language. Primary progressive aphasia or PPA is often described as an atypical variant of Alzheimer’s disease characterized by progressive breakdown of language functions with relative preservation of other cognitive skills. In this talk I am going to describe data that inform of the neural dynamics of language recovery after the stroke and changes associated with PPA. Based on these findings, my lab developed treatment protocol that combines language therapy with noninvasive neuromodulation designed to ameliorate language deficits in PPA. In the second part of the talk I will present preliminary treatment data and discus future directions for this work.